毒性（農薬）
安全性にも毒性に関係する資料を掲載していますので参照して下さい。
急性毒性
- 農薬登録における急性毒性試験では雌の使用が推奨されています。この規制のもとになった論文です。
Lipnick RL et al., Comparison of the up-and-down, conventional LD50, and fixed-dose acute toxicity procedures. Food Chem Toxicol 33:223-231, 1995.
皮膚感作性試験
- OECD等のガイドラインで引用される皮膚感作性試験の論文です。
Robinson MK et al. A review of the Buehler guinea pig skin sensitization test and its use in a risk assessment process for human skin sensitization. Toxicology 61:91-107, 1990.Magnusson B, Kligman AM. The identification of contact allergens by animal assay. The guinea pig maximization test. J Invest Dermatol 52:268-276, 1969.
Frankild S et al. Comparison of the sensitivities of the Buehler test and the guinea pig maximization test for predictive testing of contact allergy. Acta Derm Venereol 80:256-62, 2000
Ritz HL, Buehler EV. Planning, conduct and interpretation of guinea pig sensitization patch tests. In: Current Concepts in Cutaneous Toxicity (Drill, V.A. and Lazar, P., eds.), New York, Academic Press, 25-40, 1980.
吸入毒性
- 吸入毒性試験に関する吸入曝露法や沈着部位等についての報告です。
Pauluhn J. Overview of inhation exposure techniques: Srenghs and weaknesses. Exp Tox Pathol 57:111-128, 2005.
Raabe OG et al. Deposition of inhaled monodisperse aerosols in small rodents. Inhaled Particles IV
(WAlton WH and McGovern B eds), pp3-20, Pergamon Press, Oxford, 1977.
Sznitman J. Respiratory microflows in the pulmonary acinus. J Biomech 46:284-298, 2013.
神経毒性
- 神経病理学的検査に関する総説です。
Bolon B et al. “Current Pathology Techniques” symposium review: Advances and issues in neuropathology. Toxicol Pathol 36: 871-889, 2008. - 部位特異的な障害を例示して、神経毒性試験における脳切片作成のサンプリング間隔について考察しています。
Switzer RC 3rd et al. Recommended neuroanatomical sampling practices for comprehensive brain evaluation in nonclinical safety studies. Toxicol Pathol 39:73-84, 2011.
毒性メカニズム
- WHOやILSIから出されたMOA／ヒト外挿性に関する総説です。
Boobis AR et al. IPCS framework for analyzing the relevance of a noncancer mode of action for humans. Crit Rev Toxicol 38:87–96, 2008.
Meek ME et al. A framework for human relevance analysis of information on carcinogenic modes of action. Crit Rev Toxicol 33:591-653, 2003.
Seed J et al. Overview: using mode of action and life stage information to evaluate the human relevance of animal toxicity data. Crit Rev Toxicol 35:664-72, 2005.
Sonich-Mullin C et al. IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis. Regul Toxicol Pharmacol 34:146-52, 2001.
Boobis AR et al. IPCS framework for analyzing the relevance of a cancer mode of action for humans. Crit Rev Toxicol 36:781-92, 2006. - 核内受容体の発見に関する解説です。
Yan J, Xie W. A brief history of the discovery of PXR and CAR as xenobiotic receptors. Acta Pharm Sin B 6:450-452, 2016. - 雌性ラットの性成熟に関して内分泌かく乱化学物質スクリーニング及び試験法諮問委員会」（EDSTAC）が勧告したプロトコール基づいて、性・甲状腺ホルモン、神経調節機構、外部要因について幅広く解説されており、メカニズムを考察する上で有益な総説です。
Goldman JM et al. Endocrine-disrupting chemicals: Prepubertal exposures and effects on sexual maturation and thyroid activity in the female Rat. A focus on the EDSTAC recommendations. Crit Rev Toxicol 30:135-1396, 2000.
リスク評価
- 不確定係数（安全係数）に関する総説です。
Falk-Filipsson A et al. Assessment factors-Applications in health risk assessment of chemicals. Environmental Research 104:108-127, 2007.
動物（家畜）代謝
- 各種動物における代謝が記載されています。
Burkina V et al. Comparison of xenobiotic-metabolising human, porcine, rodent, and piscine cytochrome P450. Toxicology 375:10-27 2017.
Lech JJ, Bend JR. Relationship between biotransformation and the toxicity and fate of xenobiotic chemicals in fish. Environ Health Perspect 34:115-131 1980.
Scott JG. Insect cytochrome P450s: Thinking beyond detoxification. Recent advances in Insect physiology, Toxicology and Molecular Biology, 117-124 2008.
Casida JE. Unexpected Metabolic Reactions and Secondary Targets of Pesticide Action. J Agric Food Chem 64:4471-4477 2016.
Baert K, De Backer P. Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species. Comp Biochem Physiol C Toxicol Pharmacol 134:25-33 2003.
Gong Y, Diao Q. Current knowledge of detoxification mechanisms of xenobiotic in honey bees. Ecotoxicology 26:1-12 2017.
環境毒性
魚類
- メダカに関する論文です。
Perrichon P et al. Influence of sediment composition on PAH toxicity using zebrafish (Danio rerio) and Japanese medaka (Oryzias latipes) embryo-larval assays. Environ Sci Pollut Res Int 21:13703-13719, 2014.
Padilla S et al. Use of medaka in toxicity testing. Curr Protoc Toxicol Chapter 1:Unit1.10, 2009.
Grim KC et al. Intersex in Japanese medaka (Oryzias latipes) used as negative controls in toxicologic bioassays: a review of 54 cases from 41 studies. Environ Toxicol Chem 26:1636-1643, 2007.
ミジンコ
- ミジンコ試験に関する解説です。
Baird DJ et al. The Daphnia bioassay: a critique. Hydrobiologia 188/189: 403-406. 1989.
Bownik A. Daphnia swimming behaviour as a biomarker in toxicity assessment: A review. Sci Total Environ 601-602:194-205 2017.
Christie AE, McCoole MD. From genes to behavior: Investigations of neurochemical signaling come of age for the model crustacean Daphnia pulex. J Exp Biol 215:2535-2544, 2012.
ヌマエヒ゛、ヌカエヒ゛
- ヌマエヒ゛、ヌカエヒ゛に関する論文です。
Kenny NJ et al. Genomic sequence and experimental tractability of a new decapod shrimp model, Neocaridina denticulata. Mar Drugs 12:1419-1437, 2014.
Takeuchi Y et al. Morphological asymmetry of the abdomen and behavioral laterality in atyid shrimps. Zoolog Sci 25:355-363, 2008.
Huang DJ, Chen HC. Effects of chlordane and lindane on testosterone and vitellogenin levels in green neon shrimp (Neocaridina denticulata). Int J Toxicol 23:91-95, 2004.
ヨコエビ
- ヨコエヒ゛に関する論文です。
Feiner M et al. Miniature circulatory systems: A new exposure system for ecotoxicological effect assessments in riverine organisms. Environ Toxicol Chem 35:2827-2833, 2016.
Perrot-Minnot MJ et al. Modulatory effects of the serotonergic and histaminergic systems on reaction to light in the crustacean Gammarus pulex. Neuropharmacology 75:31-37, 2013.
Costa FO et al. Acute marine sediment toxicity: a potential new test with the amphipod Gammarus locusta. Ecotoxicol Environ Saf 40:81-87, 1998.
ユスリカ
- ユスリカに関する論文です。
Marus EM et al. A New Toxicity Test Using the Freshwater Copepod Cyclops vernalis. Bull Environ Contam Toxicol 95:357-362, 2015.
Marinkovic M et al. Gene expression patterns and life cycle responses of toxicant-exposed chironomids. Environ Sci Technol 46:12679-12686, 2012.
Taenzler V et al. Chironomids: suitable test organisms for risk assessment investigations on the potential endocrine disrupting properties of pesticides. Ecotoxicology 16:221-230, 2007.
藻類
- 藻類に関する論文です。
Kruger O et al. New approach to the ecotoxicological risk assessment of artificial outdoor sporting grounds. Environ Pollut 175:69-74, 2013.
Rendal C et al. Critical evaluation and further development of methods for testing ecotoxicity at multiple pH using Daphnia magna and pseudokirchneriella subcapitata. Environ Toxicol Chem 31:1843-1852, 2012.
Cleuvers M et al. Combination effect of light and toxicity in algal tests. J Environ Qual 31:539-547, 2002.
ミツバチ
- 西洋ミツバチの分布や近年のミツハ゛チ減少に関する報告です。
Han F eta al. From where did the Western honeybee (Apis mellifera) originate? Ecol Evol 2:1949-1957, 2012.
Becher MA et al. Towards a systems approach for understanding honeybee decline: a stocktaking and synthesis of existing models.
J Appl Ecol 50:868-880 2013.
蚕
- 蚕に関する論文です。
Hamamoto H wt al. Silkworm as a model animal to evaluate drug candidate toxicity and metabolism. Comp Biochem Physiol C Toxicol
Pharmacol 149:334-339, 2009.
鳥類
- 鳥類に関する論文です。
Seredynski AL et al. Specific activation of estrogen receptor alpha and beta enhances male sexual behavior and neuroplasticity in male
Japanese quail. PLoS One 6:e18627, 2011.
Nain S, Smits JE. Subchronic lead exposure, immunotoxicology and increased disease resistance in Japanese quail (Corturnix coturnix
japonica). Ecotoxicol Environ Saf 74:787-792, 2011.
Sahin K et al. Genistein suppresses spontaneous oviduct tumorigenesis in quail. Nutr Cancer 61:799-806, 2009.
Romijn CA et al. The use of Japanese and bobwhite quail as indicator species in avian toxicity test. ECPA/GIFAP Environmental Round
able. Chemosphere 30:1033-1040, 1995.